Interleukin-1 receptor
| interleukin 1 receptor, type I | |
|---|---|
| Identifiers | |
| Symbol | IL1R1 |
| Alt. symbols | IL1R, IL1RA |
| Entrez | 3554 |
| HUGO | 5993 |
| OMIM | 147810 |
| RefSeq | NM_000877 |
| UniProt | P14778 |
| Other data | |
| Locus | Chr. 2 q12 |
| interleukin 1 receptor, type II | |
|---|---|
| Identifiers | |
| Symbol | IL1R2 |
| Alt. symbols | IL1RB |
| Entrez | 7850 |
| HUGO | 5994 |
| OMIM | 147811 |
| RefSeq | NM_173343 |
| UniProt | P27930 |
| Other data | |
| Locus | Chr. 2 q12 |
| interleukin 1 receptor accessory protein | |
|---|---|
| Identifiers | |
| Symbol | IL1RAP |
| Alt. symbols | IL-1RAcP, IL1R3, C3orf13 |
| Entrez | 3556 |
| HUGO | 5995 |
| OMIM | 602626 |
| RefSeq | NM_134470 |
| UniProt | Q9NPH3 |
| Other data | |
| Locus | Chr. 3 q28 |
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.[1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding.[1] Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).[2]
The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction.[3]
References
^ ab Kuno K, Matsushima K (1994). "The IL-1 receptor signaling pathway" (abstract page). J. Leukoc. Biol. 56 (5): 542–7. PMID 7964161..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
^ Arend WP (1991). "Interleukin 1 receptor antagonist. A new member of the interleukin 1 family". J. Clin. Invest. 88 (5): 1445–51. doi:10.1172/JCI115453. PMC 295645. PMID 1834696.
^ Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU (March 1997). "The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases)". J. Biol. Chem. 272 (12): 7727–31. doi:10.1074/jbc.272.12.7727. PMID 9065432.
External links
Receptors,+Interleukin-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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