MAFA, RIPE3b1, hMafA, MAF bZIP transcription factor A, INSDM
External IDs
MGI: 2673307 HomoloGene: 65867 GeneCards: MAFA
Gene location (Human)
Chr.
Chromosome 8 (human)[1]
Band
8q24.3
Start
143,419,182 bp[1]
End
143,430,406 bp[1]
Gene location (Mouse)
Chr.
Chromosome 15 (mouse)[2]
Band
15|15 D3
Start
75,745,490 bp[2]
End
75,748,228 bp[2]
RNA expression pattern
More reference expression data
Gene ontology
Molecular function
• transcription factor activity, sequence-specific DNA binding • protein heterodimerization activity • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein homodimerization activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Cellular component
• cell nucleus
Biological process
• regulation of transcription, DNA-templated • response to glucose • insulin secretion • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • nitric oxide mediated signal transduction • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
389692
378435
Ensembl
ENSG00000182759
ENSMUSG00000047591
UniProt
Q8NHW3
Q8CF90
RefSeq (mRNA)
NM_201589
NM_194350
RefSeq (protein)
NP_963883
NP_919331
Location (UCSC)
Chr 8: 143.42 – 143.43 Mb
Chr 15: 75.75 – 75.75 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Transcription factor MafA is a protein that in humans is encoded by the MAFA gene.[5] It is a member of the Maf family of transcription factors.[6]
Contents
1MAFA assists in insulin regulation
2Interactions
3References
4Further reading
MAFA assists in insulin regulation
An in vivo study on mice proved MafA binds to the promoter in an insulin gene to regulate insulin transcription in response to serum glucose levels.[7] MafA is a β cell-specific activator, which differentiates it from other transcription factors involved with insulin gene expression.[8] It helps regulate the β cells involved with insulin secretion primarily by maintaining β cell metabolism.[9] The amount of MafA in the β cells is regulated by levels of glucose and oxidative stress.[6]
Interactions
MafA (gene) has been shown to interact with NEUROD1[10] and Pdx1.[10] MafA works with Pdx1 to activate the insulin gene.[6]
References
^ abcGRCh38: Ensembl release 89: ENSG00000182759 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000047591 - Ensembl, May 2017
^"Entrez Gene: MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)".
^ abcAramata; Han (2007). "Roles and Regulation of Transcription Factor MafA in Islet β-cells". Endocr. J. 54 (5): 659–66. doi:10.1507/endocrj.kr-101. PMID 17785922.
^Zhang; Moriguchi (2005). "MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion". Mol. Cell. Biol. 25 (12): 4969–4976. doi:10.1128/MCB.25.12.4969-4976.2005. PMC 1140590. PMID 15923615.
^Matsuoka; Artner (March 2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2930–3. Bibcode:2004PNAS..101.2930M. doi:10.1073/pnas.0306233101. PMC 365722. PMID 14973194.
Benkhelifa S, Provot S, Nabais E, et al. (2001). "Phosphorylation of MafA is essential for its transcriptional and biological properties". Mol. Cell. Biol. 21 (14): 4441–52. doi:10.1128/MCB.21.14.4441-4452.2001. PMC 87104. PMID 11416124.
Olbrot M, Rud J, Moss LG, Sharma A (2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6737–42. Bibcode:2002PNAS...99.6737O. doi:10.1073/pnas.102168499. PMC 124472. PMID 12011435.
Kataoka K, Han SI, Shioda S, et al. (2003). "MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene". J. Biol. Chem. 277 (51): 49903–10. doi:10.1074/jbc.M206796200. PMID 12368292.
Matsuoka TA, Artner I, Henderson E, et al. (2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2930–3. Bibcode:2004PNAS..101.2930M. doi:10.1073/pnas.0306233101. PMC 365722. PMID 14973194.
Kaneto H, Matsuoka TA, Nakatani Y, et al. (2005). "A crucial role of MafA as a novel therapeutic target for diabetes". J. Biol. Chem. 280 (15): 15047–52. doi:10.1074/jbc.M412013200. PMID 15664997.
Harmon JS, Stein R, Robertson RP (2005). "Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells". J. Biol. Chem. 280 (12): 11107–13. doi:10.1074/jbc.M410345200. PMID 15664999.
Zhao L, Guo M, Matsuoka TA, et al. (2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription". J. Biol. Chem. 280 (12): 11887–94. doi:10.1074/jbc.M409475200. PMID 15665000.
Aramata S, Han SI, Yasuda K, Kataoka K (2005). "Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1". Biochim. Biophys. Acta. 1730 (1): 41–6. doi:10.1016/j.bbaexp.2005.05.009. PMID 15993959.
Raum JC, Gerrish K, Artner I, et al. (2006). "FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site". Mol. Cell. Biol. 26 (15): 5735–43. doi:10.1128/MCB.00249-06. PMC 1592775. PMID 16847327.
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