Thyrotropin-releasing hormone receptor































































TRHR
Identifiers
Aliases
TRHR, TRH-R, thyrotropin releasing hormone receptor
External IDs OMIM: 188545 MGI: 98824 HomoloGene: 20707 GeneCards: TRHR


















Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]

Chromosome 8 (human)
Genomic location for TRHR

Genomic location for TRHR

Band 8q23.1 Start 109,086,621 bp[1]
End 109,119,584 bp[1]























RNA expression pattern
PBB GE TRHR 211438 at fs.png
More reference expression data















Orthologs
Species Human Mouse
Entrez


7201


22045
Ensembl


ENSG00000174417


ENSMUSG00000038760
UniProt


P34981


P21761
RefSeq (mRNA)


NM_003301


NM_013696
RefSeq (protein)


NP_003292


NP_038724
Location (UCSC) Chr 8: 109.09 – 109.12 Mb Chr 15: 44.2 – 44.24 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.[5][6]


The TRHR are found in the brain and when bound by TRH act (through phospholipase C) to increase intracellular inositol trisphosphate.



References





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000174417 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000038760 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Mouse PubMed Reference:".


  5. ^ Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317.


  6. ^ Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: cloning and regulation of its expression". Recent Progress in Hormone Research. 48: 341–63. PMID 8382829.




Further reading


.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}



  • Short RE, James LF, Panter KE, Staigmiller RB, Bellows RA, Malcolm J, Ford SP (November 1992). "Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep". Journal of Animal Science. 70 (11): 3498–504. PMID 1459912.


  • Yamada M, Iwasaki T, Satoh T, Monden T, Konaka S, Murakami M, Iriuchijima T, Mori M (August 1995). "Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly". Neuroscience Letters. 196 (1–2): 109–12. doi:10.1016/0304-3940(95)11861-P. PMID 7501234.


  • Hinuma S, Hosoya M, Ogi K, Tanaka H, Nagai Y, Onda H (October 1994). "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene". Biochimica et Biophysica Acta. 1219 (2): 251–9. doi:10.1016/0167-4781(94)90046-9. PMID 7918619.


  • Morrison N, Duthie SM, Boyd E, Eidne KA, Connor JM (June 1994). "Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization". Human Genetics. 93 (6): 716–8. doi:10.1007/bf00201580. PMID 8005602.


  • Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID 8128317.


  • Duthie SM, Taylor PL, Anderson L, Cook J, Eidne KA (September 1993). "Cloning and functional characterisation of the human TRH receptor". Molecular and Cellular Endocrinology. 95 (1–2): R11–5. doi:10.1016/0303-7207(93)90043-J. PMID 8243797.


  • Matre V, Karlsen HE, Wright MS, Lundell I, Fjeldheim AK, Gabrielsen OS, Larhammar D, Gautvik KM (August 1993). "Molecular cloning of a functional human thyrotropin-releasing hormone receptor". Biochemical and Biophysical Research Communications. 195 (1): 179–85. doi:10.1006/bbrc.1993.2027. PMID 8395824.


  • Yamada M, Monden T, Satoh T, Satoh N, Murakami M, Iriuchijima T, Kakegawa T, Mori M (September 1993). "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene". Biochemical and Biophysical Research Communications. 195 (2): 737–45. doi:10.1006/bbrc.1993.2107. PMID 8396925.


  • Iwasaki T, Yamada M, Satoh T, Konaka S, Ren Y, Hashimoto K, Kohga H, Kato Y, Mori M (September 1996). "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene". The Journal of Biological Chemistry. 271 (36): 22183–8. doi:10.1074/jbc.271.36.22183. PMID 8703031.


  • Cook JV, McGregor A, Lee T, Milligan G, Eidne KA (July 1996). "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor". Endocrinology. 137 (7): 2851–8. doi:10.1210/en.137.7.2851. PMID 8770906.


  • Collu R, Tang J, Castagné J, Lagacé G, Masson N, Huot C, Deal C, Delvin E, Faccenda E, Eidne KA, Van Vliet G (May 1997). "A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 82 (5): 1561–5. doi:10.1210/jc.82.5.1561. PMID 9141550.


  • Petrou C, Tashjian AH (September 1998). "The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles". Cellular Signalling. 10 (8): 553–9. doi:10.1016/S0898-6568(97)00190-3. PMID 9794253.


  • Matre V, Høvring PI, Orstavik S, Frengen E, Rian E, Velickovic Z, Murray-McIntosh RP, Gautvik KM (January 1999). "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor". Journal of Neurochemistry. 72 (1): 40–50. doi:10.1046/j.1471-4159.1999.0720040.x. PMID 9886052.


  • Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, Eidne KA (April 2001). "Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer". The Journal of Biological Chemistry. 276 (16): 12736–43. doi:10.1074/jbc.M011311200. PMID 11278883.


  • Zhu CC, Cook LB, Hinkle PM (August 2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation". The Journal of Biological Chemistry. 277 (31): 28228–37. doi:10.1074/jbc.M204221200. PMID 12023974.


  • Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA (December 2002). "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2". The Journal of Biological Chemistry. 277 (52): 50422–30. doi:10.1074/jbc.M209340200. PMID 12393857.


  • Cook LB, Zhu CC, Hinkle PM (September 2003). "Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation". Molecular Endocrinology. 17 (9): 1777–91. doi:10.1210/me.2003-0073. PMID 12805411.


  • Igarashi-Migitaka J, Yamada S, Hara M, Sano T, Ozawa Y, Ohtani-Kaneko R, Hirata K (August 2003). "Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas". Endocrine Journal. 50 (4): 459–67. doi:10.1507/endocrj.50.459. PMID 14599121.


  • Cook LB, Hinkle PM (July 2004). "Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein". Endocrinology. 145 (7): 3095–100. doi:10.1210/en.2004-0304. PMID 15117874.




External links




  • "Thyrotropin-Releasing Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.


  • Receptors,+Thyrotropin-Releasing+Hormone at the US National Library of Medicine Medical Subject Headings (MeSH)











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