Thrombin receptor
Multi tool use
There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). [1]
These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it.
References
^ "Thrombin receptors and their antagonists: an update on the patent literature". Expert Opin Ther Pat. 20 (7): 875–84. Jul 2010. doi:10.1517/13543776.2010.487864. PMID 20450349. Retrieved 8 April 2013..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
Membrane proteins, receptors: cell surface receptors
|
|---|
| G protein–coupled receptor |
| Class A |
Eicosanoid receptor (Prostaglandin receptor)
- Protease-activated receptor
- Neurotransmitter receptor
- Purinergic receptor
- Biogenic amine receptor
- Olfactory receptor
|
| Class B |
|
| Class C |
- Metabotropic glutamate receptor
|
| Class D |
|
| Class E |
|
| Class F |
|
|
| Ligand-gated ion channel |
|
| Enzyme-linked receptor |
- Serine/threonine-specific protein kinase
- Receptor tyrosine kinase
- Guanylate cyclase
|
| Other/ungrouped |
- Asialoglycoprotein receptor
- Tumor necrosis factor receptor
- Immunoglobulin superfamily
N-Acetylglucosamine receptor
- Neuropilins
- Transferrin receptor
- EDAR
- Lipoprotein receptor-related protein
- Progestin and adipoQ receptor
|
Cell surface receptor: G protein-coupled receptors
|
|---|
|
Class B: Secretin-like
|
|---|
| Adhesion |
|
| Orphan |
GPR (56
- 64
- 97
- 98
- 110
- 111
- 112
- 113
- 114
- 115
- 116
- 123
- 124
- 125
- 126
- 128
- 133
- 143
- 144
- 155
157)
|
| Other |
Brain-specific angiogenesis inhibitor (1
- 2
3)
Cadherin (1
- 2
3)
- Calcitonin
- CALCRL
- CD97
Corticotropin-releasing hormone (1
2)
EMR (1
- 2
3)
Glucagon (GR
- GIPR
- GLP1R
GLP2R)
- Growth-hormone-releasing hormone
- PACAPR1
- GPR
Latrophilin (1
- 2
- 3
ELTD1)
- Methuselah-like proteins
Parathyroid hormone (1
2)
- Secretin
Vasoactive intestinal peptide (1
2)
|
|
|
Class C: Metabotropic glutamate / pheromone
|
|---|
| Taste |
TAS1R (1
- 2
3)
TAS2R (1
- 3
- 4
- 5
- 7
- 8
- 9
- 10
- 13
- 14
- 16
- 19
- 20
- 30
- 31
- 38
- 39
- 40
- 41
- 42
- 43
- 45
- 46
- 50
- 60
Vomeronasal receptor)
|
| Other |
- Calcium-sensing receptor
GABAB (1
2)
Glutamate receptor (Metabotropic glutamate (1
- 2
- 3
- 4
- 5
- 6
- 7
8))
- GPRC6A
GPR (156
- 158
179)
RAIG (1
- 2
- 3
4)
|
|
|
Class F: Frizzled & Smoothened
|
|---|
| Frizzled |
Frizzled (1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
10)
|
| Smoothened |
|
|
|
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