Skip to main content

Enolase 2









Enolase 2


From Wikipedia, the free encyclopedia

Jump to navigation
Jump to search






























































ENO2
Protein ENO2 PDB 1te6.png







Available structures
PDB Ortholog search: PDBe RCSB



Identifiers
Aliases
ENO2, HEL-S-279, NSE, Enolase 2
External IDs MGI: 95394 HomoloGene: 74414 GeneCards: ENO2


















Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]

Chromosome 12 (human)
Genomic location for ENO2

Genomic location for ENO2

Band 12p13.31 Start 6,913,745 bp[1]
End 6,923,698 bp[1]























RNA expression pattern
PBB GE ENO2 201313 at fs.png
More reference expression data















Orthologs
Species Human Mouse
Entrez


2026


13807
Ensembl


ENSG00000111674


ENSMUSG00000004267
UniProt


P09104
Q6FHV6


P17183
RefSeq (mRNA)


NM_001975


NM_013509
NM_001302642
NM_001355220
RefSeq (protein)


NP_001966
NP_001966.1


NP_001289571
NP_038537
NP_001342149
Location (UCSC) Chr 12: 6.91 – 6.92 Mb Chr 6: 124.76 – 124.77 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[5][6] Gamma-enolase is a phosphopyruvate hydratase.


Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[5]




Contents






  • 1 Interactive pathway map


  • 2 Utility


  • 3 References


  • 4 Further reading





Interactive pathway map[edit]


Click on genes, proteins and metabolites below to link to respective articles. [§ 1]






[[File:




GlycolysisGluconeogenesis_WP534go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to WikiPathways
go to article
go to Entrez
go to article



[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]

[[
]]



GlycolysisGluconeogenesis_WP534go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to article
go to WikiPathways
go to article
go to Entrez
go to article




|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]



Glycolysis and Gluconeogenesis edit







  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}





Utility[edit]




Neuron-specific enolase (NSE) immunostaining of a cerebellar hemangioblastoma.


Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small cell carcinomas which are neuroendocrine in origin. NSE is therefore a useful tumor marker for lung cancer patients.[7]



References[edit]





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000111674 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000004267 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:".


  4. ^ "Mouse PubMed Reference:".


  5. ^ ab "ENO2 enolase 2 (gamma, neuronal)". NCBI Entrez Gene database.


  6. ^ Online Mendelian Inheritance in Man (OMIM) Enolase 2 -131360


  7. ^ Clegg N, Ferguson C, True LD, Arnold H, Moorman A, Quinn JE, Vessella RL, Nelson PS (April 2003). "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55–64. doi:10.1002/pros.10217. PMID 12640661.




Further reading[edit]


.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}



  • Oliva D, Calì L, Feo S, Giallongo A (1991). "Complete structure of the human gene encoding neuron-specific enolase". Genomics. 10 (1): 157–65. doi:10.1016/0888-7543(91)90496-2. PMID 2045099.


  • Craig SP, Day IN, Thompson RJ, Craig IW (1991). "Localisation of neurone-specific enolase (ENO2) to 12p13". Cytogenet. Cell Genet. 54 (1–2): 71–3. doi:10.1159/000132960. PMID 2249478.


  • Oliva D, Barba G, Barbieri G, et al. (1989). "Cloning, expression and sequence homologies of cDNA for human gamma enolase". Gene. 79 (2): 355–60. doi:10.1016/0378-1119(89)90217-5. PMID 2792767.


  • McAleese SM, Dunbar B, Fothergill JE, et al. (1989). "Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE)". Eur. J. Biochem. 178 (2): 413–7. doi:10.1111/j.1432-1033.1988.tb14465.x. PMID 3208766.


  • Van Obberghen E, Kamholz J, Bishop JG, et al. (1988). "Human gamma enolase: isolation of a cDNA clone and expression in normal and tumor tissues of human origin". J. Neurosci. Res. 19 (4): 450–6. doi:10.1002/jnr.490190409. PMID 3385803.


  • Day IN, Allsopp MT, Moore DC, Thompson RJ (1987). "Sequence conservation in the 3'-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs". FEBS Lett. 222 (1): 139–43. doi:10.1016/0014-5793(87)80207-7. PMID 3653393.


  • Haimoto H, Takahashi Y, Koshikawa T, et al. (1985). "Immunohistochemical localization of gamma-enolase in normal human tissues other than nervous and neuroendocrine tissues". Lab. Invest. 52 (3): 257–63. PMID 3974199.


  • Quan CP, Watanabe S, Vuillier F, et al. (1993). "Purification and partial amino acid sequence of suppressive lymphokine from a CD8+ CD57+ human T hybridoma". Immunology. 78 (2): 205–9. PMC 1421811. PMID 7682534.


  • Angelov DN, Neiss WF, Gunkel A, et al. (1994). "Axotomy induces intranuclear immunolocalization of neuron-specific enolase in facial and hypoglossal neurons of the rat". J. Neurocytol. 23 (4): 218–33. doi:10.1007/BF01275526. PMID 8035205.


  • Pechumer H, Bender-Götze C, Ziegler-Heitbrock HW (1994). "Detection of neuron-specific gamma-enolase messenger ribonucleic acid in normal human leukocytes by polymerase chain reaction amplification with nested primers". Lab. Invest. 69 (6): 743–9. PMID 8264236.


  • Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. doi:10.1101/gr.7.3.268. PMID 9074930.


  • Lau L (2002). "Neuroblastoma: a single institution's experience with 128 children and an evaluation of clinical and biological prognostic factors". Pediatric hematology and oncology. 19 (2): 79–89. doi:10.1080/08880010252825669. PMID 11881792.


  • Wijnberger LD, Nikkels PG, van Dongen AJ, et al. (2002). "Expression in the placenta of neuronal markers for perinatal brain damage". Pediatr. Res. 51 (4): 492–6. doi:10.1203/00006450-200204000-00015. PMID 11919335.


  • O'Dwyer DT, Clifton V, Hall A, et al. (2002). "Pituitary autoantibodies in lymphocytic hypophysitis target both gamma- and alpha-Enolase - a link with pregnancy?". Arch. Physiol. Biochem. 110 (1–2): 94–8. doi:10.1076/apab.110.1.94.897. PMID 11935405.


  • Chekhonin VP, Zhirkov YA, Belyaeva IA, et al. (2002). "Serum time course of two brain-specific proteins, alpha(1) brain globulin and neuron-specific enolase, in tick-born encephalitis and Lyme disease". Clin. Chim. Acta. 320 (1–2): 117–25. doi:10.1016/S0009-8981(02)00057-8. PMID 11983209.


  • Nakatsuka S, Nishiu M, Tomita Y, et al. (2005). "Enhanced expression of neuron-specific enolase (NSE) in pyothorax-associated lymphoma (PAL)". Jpn. J. Cancer Res. 93 (4): 411–6. doi:10.1111/j.1349-7006.2002.tb01272.x. PMID 11985791.


  • Fujiwara H, Arima N, Ohtsubo H, et al. (2002). "Clinical significance of serum neuron-specific enolase in patients with adult T-cell leukemia". Am. J. Hematol. 71 (2): 80–4. doi:10.1002/ajh.10190. PMID 12353304.


  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • Rodríguez-Núñez A, Cid E, Rodríguez-García J, et al. (2003). "Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis". Brain Dev. 25 (2): 102–6. doi:10.1016/S0387-7604(02)00160-2. PMID 12581805.


  • Muley T, Ebert W, Stieber P, et al. (2003). "Technical performance and diagnostic utility of the new Elecsys neuron-specific enolase enzyme immunoassay". Clin. Chem. Lab. Med. 41 (1): 95–103. doi:10.1515/CCLM.2003.017. PMID 12636057.
















Retrieved from "https://en.wikipedia.org/w/index.php?title=Enolase_2&oldid=798117752"





Navigation menu

























(window.RLQ=window.RLQ||).push(function(){mw.config.set({"wgPageParseReport":{"limitreport":{"cputime":"0.928","walltime":"1.113","ppvisitednodes":{"value":5036,"limit":1000000},"ppgeneratednodes":{"value":0,"limit":1500000},"postexpandincludesize":{"value":292919,"limit":2097152},"templateargumentsize":{"value":94562,"limit":2097152},"expansiondepth":{"value":11,"limit":40},"expensivefunctioncount":{"value":28,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":68082,"limit":5000000},"entityaccesscount":{"value":29,"limit":400},"timingprofile":["100.00% 913.430 1 -total"," 51.65% 471.779 1 Template:Infobox_gene"," 19.74% 180.293 21 Template:Cite_journal"," 14.22% 129.864 1 Template:GlycolysisGluconeogenesis_WP534"," 9.98% 91.128 1 Template:CSS_image_crop"," 9.14% 83.516 1 Template:Annotated_image"," 7.75% 70.771 12 Template:Navbox"," 7.59% 69.355 2 Template:Reflist"," 3.54% 32.373 75 Template:Annotation"," 3.45% 31.539 1 Template:PDB_Gallery"]},"scribunto":{"limitreport-timeusage":{"value":"0.597","limit":"10.000"},"limitreport-memusage":{"value":7314123,"limit":52428800}},"cachereport":{"origin":"mw1255","timestamp":"20181118074611","ttl":1900800,"transientcontent":false}}});mw.config.set({"wgBackendResponseTime":104,"wgHostname":"mw1322"});});
-

Popular posts from this blog

Florida Star v. B. J. F.

Image
Florida Star v. B. J. F. From Wikipedia, the free encyclopedia Jump to navigation Jump to search United States Supreme Court case Florida Star v. B. J. F. Supreme Court of the United States Argued March 21, 1989 Decided June 21, 1989 Full case name The Florida Star v. B. J. F. Citations 491 U.S. 524 ( more ) 109 S. Ct. 2603; 105 L. Ed. 2d 443; 1989 U.S. LEXIS 3120; 57 U.S.L.W. 4816; 16 Media L. Rep. 1801 Prior history The Florida Star v. B.J.F., 530 So.2d 286 (1988) Supreme Court of Florida; Florida Star v. B.J.F., 499 So.2d 883 (1986) Fla. Dist. Court of Appeals Holding Florida Stat. § 794.03 is unconstitutional to the extent it makes the truthful reporting of information that was a matter of public record unlawful, as it violates the First Amendment. Court membership Chief Justice William Rehnquist Associate Justices William J. Brennan Jr.  · Byron White Thurgood Marshall  · Harry Blac...
Read more

Danny Elfman

Image
Danny Elfman From Wikipedia, the free encyclopedia Jump to navigation Jump to search Danny Elfman Elfman at the 2010 San Diego Comic-Con Born Daniel Robert Elfman ( 1953-05-29 ) May 29, 1953 (age 65) Los Angeles, California, U.S. Spouse(s) Bridget Fonda ( m.  2003) Children 1 Musical career Genres Rock [1] ska [2] new wave film music video game music Occupation(s) Composer, singer, songwriter, record producer Instruments Trombone guitar percussion vocals keyboards [3] Years active 1972–present Associated acts Oingo Boingo James Newton Howard Daniel Robert Elfman (born May 29, 1953) is an American composer, singer, songwriter, and record producer. Elfman first became known for being the lead singer and songwriter for the band Oingo Boingo from 1974 to 1995. He is well known for scoring films and television shows, particularly his frequent collabora...
Read more

Lugert, Oklahoma

Image
Unincorporated community in Oklahoma, United States Lugert, Oklahoma Unincorporated community Foundations from the town of Lugert at the bottom of Lake Altus-Lugert Lugert, Oklahoma Location within the state of Oklahoma Coordinates: 34°53′45″N 99°16′31″W  /  34.89583°N 99.27528°W  / 34.89583; -99.27528 Coordinates: 34°53′45″N 99°16′31″W  /  34.89583°N 99.27528°W  / 34.89583; -99.27528 Country United States State Oklahoma County Kiowa Time zone UTC-6 (Central (CST))  • Summer (DST) UTC-5 (CDT) GNIS feature ID 1100597 Lugert is an unincorporated community in Kiowa County, Oklahoma. [1] The town of Lugert was founded in 1901 on 80 acres (320,000 m 2 ). In the town, there was a general store that housed the Post office and sold dry goods, school supplies, groceries, harnesses, axes and much more. It was named for Frank Lugert, who had moved to the area in 1898. Lugert owned land where the town was sited and also owned the general st...
Read more